
阵发性室上性心动过速 (PSVT)
阵发性室上性心动过速(PSVT)是一种心脏节律异常(心律失常),其特征为不可预测的急性发作,心跳通常超过150-200 次/分。
SVT突然发作通常会导致心悸、呼吸短促、胸部压迫感、头晕、疲乏和焦虑。PSVT是由于心脏内异常的传导通路引起心脏的不规则收缩所致。
在中国,每1000中约有2.3-4人患有PSVT,因此估计总患者人数为300-600万。目前终止急性发作的治疗需要急诊静脉注射钙通道阻滞剂和静脉注射抗心律失常药物。患者通常每年会有多次无法预测的PSVT发作,对其生活质量产生重大影响。
Etripamil鼻喷雾剂是一种创新性的钙通道阻滞剂,旨在减少患者的急诊(ER)和手术室(OR)就诊次数。Etripamil可以自行给药,使患者能够在院外接受方便有效的快速治疗。Etripamil可用于显著改变PSVT的急性治疗方案,使患者能够快速终止发作,而不必担心或匆忙前往医院接受治疗。
参考文献:
-
Chiang JK, Kao HH, Kao YH. Association of Paroxysmal Supraventricular Tachycardia with Ischemic Stroke: A National Case-Control Study. Journal of Stroke and Cerebrovascular Diseases (2017); 26(7):1493-1499.
-
Chan CL, Li AA, Chung HA, Phan DV. Cost Effectiveness Analysis and Payment Policy Recommendation-Population-Based Survey with Big Data Methodology for Readmission Prevention of Patients with Paroxysmal Supraventricular Tachycardia treated with Radiofrequency Catheter Ablation. International Journal of Environmental Research and Public Health (2020); 17(7):2334.
-
Ho HH, Yeh SJ, Tsai WP, et al. Paroxysmal supraventricular tachycardia and Wolff-Parkinson-White syndrome in ankylosing spondylitis: a large cohort observation study and literature review. Seminars in Arthritis and Rheumatism (2012); 42(3):246-53.
-
Orejarena LA, Vidaillet H Jr, DeStefano F, et al. Paroxysmal supraventricular tachycardia in the general population. Journal of the American College of Cardiology (1998); 31(1):150-7.