Hypertension is the chronic non-infectious disease with the largest number of patients and also the leading modifiable risk factor for cardiovascular disease in China.

There are approximately 1.28 billion hypertension patients in the world and approximately 245 million hypertension patients in China. Epidemiological surveys show that the awareness rate, treatment rate and control rate of hypertension in China are 51.6%, 45.8% and 16.8%, respectively, which are all relatively low.

The Renin-Angiotensin-Aldosterone System plays a critical role to regulate the fluids and electrolytes balances in humans. Inhibition of aldosterone synthase has been proven effective at clinical setting for numerous cardiometabolic disease. 

JX09 (formerly called PB6440) is a next-generation, highly selective aldosterone synthase inhibitor. Preclinical data suggest that JX09 offers strong potency inhibiting aldosterone synthase, with very little impact on the biological functions of a homologous enzyme that is key to cortisol synthesis. The high potency and selectivity make JX09 a potential best-in-class drug candidate. 


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  • Pitt B, Bhatt D, et al, Inhibition Of Aldosterone Synthesis In Non-human Primates By PB6440, The Novel Highly Selective And Potent CYP11B2 Inhibitor, Hypertension 2020, 76, AP233.

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